The purpose of this study was to find out the factors influencing choice of school subjects by senior secondary students in Oredo Local Government Area of Edo state. The study was aimed at ascertaining the factors influencing the choice of subjects by senior secondary school students. In the process of carrying out the study, questionnaires were administered to six (6) different secondary schools. The data collected were analyzed and interpreted simple percentage method. The point of emphasis is to find solutions to the highlighted problems hindering the choice of subjects by senior secondary school students of Edo state. The recommendation include government should recognize the importance of career counsellors in secondary schools. There should be reduction of the subjects offered in senior secondary schools and also provides conducive learning environment for the secondary school students.